What was a significant consequence of the Brexit referendum in 2016?

The choice regarding the raising of questions about national sovereignty within the EU as a significant consequence of the Brexit referendum in 2016 is accurate because Brexit highlighted ongoing debates about the balance of power between individual member states and the overarching authority of the European Union. The decision of the United Kingdom to leave the EU underscored concerns regarding national sovereignty, as many voters expressed a desire to take back control over laws, borders, and trade policies. This event prompted other EU countries to reconsider their relationship with the union and fostered discussions about the degree to which EU governance could limit national autonomy.

While other options touch on economic and geographical implications, they do not capture the essence of the conversation regarding sovereignty that Brexit incited. The referendum and its aftermath sparked significant dialogue about what it means to be part of a supranational organization and led to increased scrutiny of the EU's influence over member states.